Science and technology:
From removing pathology to restoring connectivity
Why mRNA
•Transient expression, no risk of gene integration
•Rapid design and manufacturing for multi-target combinations
•Cost-controlled and globally scalable
Differentiated Innovation
•Focus on 'functional restoration' rather than Aβ/Tau removal only
•Controlled immune activation favoring B-cell responses, reducing autoimmunity risk.
•Taking on DNA vaccine lead evidence, upgrading to mRNA generation.
Past evidence (animal models, DNA vaccine phase)
DNA vaccines encoding NOIs epitopes reduced amyloid burden, preserved cognition, and enabled axonal regeneration in AD mouse models. These studies validate NOIs antigens as therapeutic targets.